Synthesis and Biological Evaluation of Tetramethylpyrazine Nitrates as Potential Anti-ischemic Stroke Agent
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چکیده
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Sinapic Acid Derivatives as Potential Anti-Inflammatory Agents: Synthesis and Biological Evaluation
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Transcription factor NF-κB and relevant cytokines IL-6 and IL-8 play a pivotal role in thepathogenesis of inflammation. Sinapic acid is a natural product and was demonstrated to possessanti-inflammatory activity. In this paper, we synthesized a series of sinapic acid derivativesand evaluated their anti-inflammatory effects. The result suggested that all of the targetscompounds 7a-j inhibit NF-κ...
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TBN, a novel tetramethylpyrazine derivative armed with a powerful free radical-scavenging nitrone moiety, has been reported to reduce cerebral infarction in rats through multi-functional mechanisms of action. Here we study the therapeutic effects of TBN on non-human primate model of stroke. Thirty male Cynomolgus macaques were subjected to stroke with 4 hours ischemia and then reperfusion. TBN ...
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A novel one-pot two step tandem reaction for the synthesis of indolizine-1-carbonitrile derivatives (5a-i) was identified. The route comprises 1,3-dipolar cycloaddition reaction of aromatic aldehyde derivatives (1a-i), malononitrile (2) and 1-(2-(4-bromophenyl)-2-oxoethyl)-2-chloropyridin-1-ium (4) under ultrasound irradiation at room temperature in the presence of triethylamine at acetonitrile...
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A novel one-pot two step tandem reaction for the synthesis of indolizine-1-carbonitrile derivatives (5a-i) was identified. The route comprises 1,3-dipolar cycloaddition reaction of aromatic aldehyde derivatives (1a-i), malononitrile (2) and 1-(2-(4-bromophenyl)-2-oxoethyl)-2-chloropyridin-1-ium (4) under ultrasound irradiation at room temperature in the presence of triethylamine at acetonitrile...
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ژورنال
عنوان ژورنال: Asian Journal of Chemistry
سال: 2016
ISSN: 0970-7077,0975-427X
DOI: 10.14233/ajchem.2016.19941